Glutathione (GSH) and the Immune System

Enhancement of systemic immune function

The immune system works best if the lymphoid cells have properly balanced glutathione. The cloning of T-cells consumes large quantiles of cysteine. Macrophages (A type of white blood cell), which are only present in enough quantiles when there is enough glutathione, provide the cysteine for the T-cell cloning. Glutathione regulates the binding, internalization, degradation, and T-cell proliferation by increasing, as much as two times, the number of binding cellular receptors. More receptors equate to more T-cells being produced simultaneously (multiple T-cell cloning). Cellular GSH also affects the growth and replication of T-cells through growth-stimulating 

Enhancement of humoral immune function

The role of glutathione in the humoral response is that it protects the cells from taking part in the humoral response all along this complex process.
A quick synopsis of the humoral immune response: “humoral” means circulating in the bloodstream. This is an immune response (chiefly against bacterial invasion) that is mediated by B cells and involves the transformation of B cells into plasma cells that produce and secrete antibodies to a specific antigen.
The process in a nutshell: macrophages engulf and digest the invading pathogen. The digested pieces activate helper T cells, which in turn activate the proliferation of B cells that are programmed for the specific invading pathogen. 

Summary in Layman’s Terms

As soon as a pathogen or virus enters the body, if there is an adequate quantity of glutathione (GSH), the glutathione enables the proliferation of attack cells to stop the invading pathogen or virus.  Enhancing your glutathione levels enhances your immune system to protect you from germs and viruses.

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** MagicalGSH LLC Disclaimer: The author of this article promotes a competing product called Glutathione 1.5 for glutathione enhancement by a suppository.  We neither endorse this product or any of the other statements other than the science of glutathione which is universal with currently over 130,000 studies in PubMed.  We stand behind Riboceine which has 22 studies in PubMed.


With over 160,000 studies and articles on glutathione in PubMed, the electronic database maintained by the U.S. National Library of Medicine, its benefits and functions are inarguable. These studies reveal the remarkable role glutathione plays in the protection and function of every cell in the human body and the support of optimal health and function.

FDA Disclaimer​ These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.